Science

Science

Blinatumomab in B-ALL: BiTE Structure, Mechanism, Resistance & Trials

Author: Alisha G C Abstract Blinatumomab is a first-in-class bispecific T-cell engager (BiTE) antibody that has fundamentally reshaped the therapeutic landscape of relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). By physically linking endogenous cytotoxic T cells to CD19-expressing malignant B cells, Blinatumomab enables potent, major histocompatibility complex (MHC)–independent T-cell cytotoxicity, thereby overcoming critical limitations […]

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Our Understanding of Universe is Built on an Assumption – Cosmological Principle

The Cosmological Principle is a fundamental idea in cosmology that states the universe is uniform (homogeneous) and looks the same in all directions (isotropic) when viewed on large scales, despite local irregularities. Homogeneity is a property that describes something with similar elements throughout, like milk, which has a uniform consistency even though it contains various

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TWA 7 b: James Webb Space Telescope Finds Its First New Exoplanet

The James Webb Space Telescope, launched in 2021 and on active duty since 2022, has gotten its legs viewing already known exoplanets but can now take credit for its first direct image of a previously unknown one.  Exoplanets have been detected since 1992 when two, named named Poltergeist and Phobetor, were found orbiting the pulsar PSR

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Whaling may have started 1,500 years earlier than already known

Whale hunting began far earlier — and much farther south — than scientists previously suspected. Five-thousand-year-old whalebone harpoons and other artifacts along Brazil’s southern coast suggest that Indigenous communities actively hunted whales at least 1,500 years before the earliest evidence to date, researchers report January 9 in Nature Communications. The findings not only rewrite the

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AI reveals 800 never-before-seen ‘cosmic anomalies’ in old Hubble images

January 27, 2026 1 min read Add Us On GoogleAdd SciAm AI reveals 800 never-before-seen ‘cosmic anomalies’ in old Hubble images Scientists analyzed more than 100 million image cutouts from a Hubble Space Telescope archive and found hundreds of previously undiscovered objects By Jackie Flynn Mogensen edited by Claire Cameron Six previously undiscovered astrophysical objects

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Stick shaped by ancient humans is the oldest known wooden tool

Artist’s reconstruction of a Palaeolithic woman making a digging stick from an alder tree trunk G. Prieto; K. Harvati The oldest known wooden tools have been found in an opencast mine in Greece. They are 430,000 years old and were made by an unidentified species of ancient human – perhaps the ancestors of Neanderthals. Prehistoric

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Microsoft says its newest AI chip Maia 200 is 3 times more powerful than Google’s TPU and Amazon’s Trainium processor

Microsoft has revealed its new Maia 200 accelerator chip for artificial intelligence (AI) that is three times more powerful than hardware from rivals like Google and Amazon, company representatives say. This newest chip will be used in AI inference rather than training, powering systems and agents used to make predictions, provide answers to queries and

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Human Activity is Driving Rapid Sinking of World’s River Deltas – State of the Planet

The work reveals which human-driven activities are the main drivers Adapted from a press release produced by the University of California, Irvine. The sinking is placing more than 236 million people at increased flooding risk in the near future. The findings could help communities residing in deltas better prioritize immediate local interventions alongside climate adaptation

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Some Public Schools Maintain High Learning Standards

For decades, academically intensive charter schools have existed quietly across the United States, yet their role in the education system has received little formal attention. These schools are defined by a clear focus on strong academic learning, setting them apart from more familiar charter models that emphasize behavior rules or social goals. A recent national

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